i don't think it matters. neopronouns have always existed. xe/xem is one that has been around longer than the others, so i'm not sure why you used that one as an example. they/them is typically used as a catch-all, and as far as i'm aware, those with neopronouns, including myself, don't mind it.
popular neopronouns include: xe/xir/xem, ze/zir......
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