Everyone has heard of this series before, whether its the animes or manga. Either way, this series is a classic! One of the best. I personally prefer the 2003 anime version over the original ending because I felt that it was more (realistic?). It had more depth and I loved the idea of parallel worlds. Also, the 2003 anime version focused more on the brothers relationship (rather than throwing in a couple for the sake of viewers).
Fullmetal Alchemist