This manga was so confusing but it kept me hooked. The visuals were really cool and you had to pay attention to detail to barely understand what's going on. The overall world was just so interesting.
From Wikipedia: Killy, a silent loner possessing an incredibly powerful weapon known as a Gravitational Beam Emitter, wanders a vast technological world known as "The City". He is searching for Net Terminal Genes, a (possibly) extinct genetic marker that allows humans to access the "Netsphere", a sort of computerized control network for The City. The City is an immense volume of artificial structure, separated into massive "floors" by nearly-impenetrable barriers known as "Megastructure". The City is inhabited by scattered human and transhuman tribes as well as hostile cyborgs known as Silicon Life. The Net Terminal Genes appear to be the key to halting the unhindered, chaotic expansion of the Megastructure, as well as a way of stopping the murderous robot horde known as the Safeguard from destroying all of humanity
Blame!