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MISS CONNIE.
• REGINA wouldn't have died that easily because we know that she's a Boleoti but due to her pregnancy with LEONA her body weakened so she is in a state where it is hard for her to protect herself.
• To shorten it whenever a Boleoti gets pregnant their body goes into a weakened state.
• According to a source: at the that time when REGINA was pregnant with LEONA nobody was there so she was easily poisoned by MISS CONNIE or Originally named SAURA/SARA.
• Regina's death was really sad. She suffered and died alone .