Any doomed sibling or family trope?

https://www.mangago.zone/read-manga/children_of_the_rune/

https://www.mangago.zone/read-manga/sister_i_am_the_queen_in_this_life/

https://www.mangago.zone/read-manga/my_sister_who_regressed_wants_my_fiance/

https://www.mangago.zone/read-manga/the_way_to_protect_the_female_lead_s_older_brother/

https://www.mangago.zone/read-manga/the_villainess_is_a_marionette/

I’m Not That Kind of Talent
I know I'll shed my bodyweight in tears if i read the novel

Trigun