
Because he took the drug, he was told his heat would be irregular. As for why it would happen while pregnant, it is up to the author but pregnancy is a hormonal surge; a majority of women are horny while pregnant with many factors as to why they don't act upon it. Probably what's meant to be outside of the drug screwing that up.

I guess I meant the way that heat/estrus is meant to attract a partner so that you can conceive, so the body doing it again while already pregnant just didn't make sense.
I completely forgot about the drug thing happening. If it's just being used as a 'horny must fuck' plot device then I guess the logistics don't really gotta makes sense.
How is he in heat if he's pregnant?? The biology is not biology-ing.