He’s not worried about penny, he’s worried that his darling sister Yvonne is going to be punished for poisoning and potentially killing an eckhart family member. Remember that Yvonne hasn’t been officially named an eckhart yet so she’s still just a commoner guest to the Eckhart family. She’s not even a noble so she has no backing. If the investigation shows Yvonne as the one who ordered her maid to poison that cup, Yvonne is getting the chopping block. There’s no trial by peers for her. He couldn’t care less about pennys health and wellbeing. He’s only wanting to clear Yvonne’s name and if she was poisoned by Yvonne’s maid and doesn’t have lasting damage, he can argue on Yvonne’s behalf saying the maid worked alone. The only ones truly concerned about her health are: pink haired bro, prince, father and bunny man.
Wasn’t everyone talking about a spoiler about how he has incestuous feelings towards the original Yvonne? That’s why I’m saying he’s worried about Yvonne. Brainwashing is just making that feeling more intense but I think he has some not so brotherly love towards Yvonne. And the reason why this theory/ spoiler is believable is because after penny talked to the pink haired bro and dad, they were both able to break the brainwashing of their own volition. Penny has also tried to get on big bros good side but never was able to. She gave up because he will never change and that’s cause on a base level, he just straight up hates her for taking Yvonne’s place.
Maybe you misread, or someone mis-wrote? I don't read spoilers, so these are merely my own interpretations. Clearly Derrick loved Yvonne, but the kind of natural love between older brother/younger sister. It's not the same as his strained feelings for Penny.
Let's see if in the future I'm proved wrong, but for the time being I didn't see anything incest-y towards Yvonne yet.
It hurts to know he he's worried sick about Penelope in his right mind but he's under some spell or shit and he's now more annoying than he was for the entire series ╥﹏╥ anyway I'm really happy that the father doesn't take Yvonne off the suspect list ( ꈍᴗꈍ) live, laugh, love Penelope father