Responses
https://www.mangago.zone/read-manga/running_on_empty/
been a while since i read this so i don't remember the plot exactly but i immediately thought of it when i saw your question
You will probably cry reading these
https://www.mangago.zone/read-manga/nigatsu_no_eden/
https://www.mangago.zone/read-manga/haruka_tooki_ie/
Idc about the genre, doesn't even have to have romance at all, just a character running away and leaving everything behind (alone or with a lover), tragedy or happy ending idc, abuse is welcomed too