i replied to another comment wanting spoilers a few days ago so i apologize if some point 1 is redundant but here you go:
spoilers
Two major things happen before she ran away:
1. Chloe found out that Damien planned her father's bankruptcy and the murder accusation against her few chapter back which caused her a great amount of stress. She suffered bleeding and had an unstable pregnancy.
2. Chloe's gonna get the plague but she doesn't want to take the medicine since the side effect would be losing their baby. Damien forces Chloe to take the medicine after seeing how her condition worsened by the day. Damien's priority was keeping Chloe alive rather than their unborn child. Chloe lived and they fought because of it and they lost they baby. Idk if I remember this part correctly but I think Damien basically locks her in the castle after they fought since Chloe wanted a divorce and he was going to battle for the throne.
bruh does anyone have spoilers